Acrokeratoelastoidosis of Costa

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Acrokeratoelastoidosis of Costa
Autosomal dominant - en.svg
Autosomal dominant is the inheritance manner for this condition

Acrokeratoelastoidosis of Costa (also known as "Keratoelastoidosis marginalis"[1]) is a familial condition characterized by multiple keratotic papules on the dorsum of the hands and feet, palms, soles, in which electron microscopy shows rarified, abnormal elastic tissue.[2]:993[3]:214

It was characterized in 1953.[4]

Treatments such as liquid nitrogen, salicylic acid, tretinoin, and prednisone have been tried, though with limited success.[5]

See also[edit]


  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
  2. ^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
  3. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  4. ^ Costa OG (1953). "Akrokerato-elastoidosis; a hitherto undescribed skin disease". Dermatologica. 107 (3): 164–8. doi:10.1159/000256794. PMID 13116681.
  5. ^ Zhai Z, Yang X, Hao F (2006). "Acrokeratoelastoidosis". Eur J Dermatol. 16 (2): 201–2. PMID 16613753.

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External resources