Hemifacial hypertrophy

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Hemifacial hypertrophy
Autosomal dominant - en.svg
This condition is inherited in an autosomal dominant manner[1]

Hemifacial hypertrophy (also termed facial hemihypertrophy,[2] facial hemihyperplasia,[2] or Friedreich's disease)[3] abbreviated as (HFH) is rare congenital disease characterized by unilateral enlargement of the head and teeth.[4][5] It is classified as true HFH (THFH) with unilateral enlargement of the viscerocranium, and partial HFH (PHFH) in which not all structures are enlarged. Hemifacial hypertrophy can cause a wide spectrum of defects or may involve only muscle or bone.[5] it is usually treated surgically.[6] It is believed to be a minor form of hemihypertrophy.[7]


  1. ^ "OMIM Entry - 133900 - HEMIFACIAL HYPERPLASIA". omim.org. Retrieved 20 July 2017. 
  2. ^ a b Rajendran A; Sundaram S (10 February 2014). Shafer's Textbook of Oral Pathology (7th ed.). Elsevier Health Sciences APAC. p. 13. ISBN 978-81-312-3800-4. 
  3. ^ Ghom AG; Ghom SA (30 September 2014). Textbook of Oral Medicine. JP Medical Ltd. p. 125. ISBN 978-93-5152-303-1. 
  4. ^ Lee S, Sze R, Murakami C, Gruss J, Cunningham M (November 2001). "Hemifacial myohyperplasia: description of a new syndrome". Am. J. Med. Genet. 103 (4): 326–33. doi:10.1002/1096-8628(20011101)103:4<326::AID-AJMG1578>3.0.CO;2-Z. PMID 11746014. 
  5. ^ a b Islam MN, Bhattacharyya I, Ojha J, Bober K, Cohen DM, Green JG (October 2007). "Comparison between true and partial hemifacial hypertrophy". Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 104 (4): 501–9. doi:10.1016/j.tripleo.2006.11.053. PMID 17448705. 
  6. ^ Pollock RA, Newman MH, Burdi AR, Condit DP (July 1985). "Congenital hemifacial hyperplasia: an embryologic hypothesis and case report". Cleft Palate J. 22 (3): 173–84. PMID 3860311. 
  7. ^ Urban PP, Bruening R, Roland B (September 2009). "Congenital isolated hemifacial hyperplasia". J. Neurol. 256 (9): 1566–9. doi:10.1007/s00415-009-5148-9. PMID 19424770. 

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